Pagets disease of bone causes and treatments

The content may be graphic. Most women do not visit the doctor because they mistake the condition for contact dermatitis or eczema. Women who feel a lump or notice skin irritation that does not heal for over a month are advised to seek the opinion of a specialist. A person may also experience crusty, oozing, or hardened skin resembling eczema on the nipple, areola, or both.

Pagets disease of bone causes and treatments

Bone remodeling in simpler terms can be called as bone metabolism. Our bone is an active tissue. New bones are constantly being formed, while old bones are continually being destroyed.

Pagets disease of bone causes and treatments

Now, the question arises, what forms the bone and what destroys it? The bone-forming cells are known as Osteoblasts, and the bone-resorbing cells are known as Osteoclasts. In a healthy individual, the processes of bone formation and destruction are in harmony, thus maintaining a normal bone turnover.

This is followed by a compensatory overactivity of osteoblasts, leading to new bone formation. But, the matter of concern here is that the new bone formed is weaker, larger, has an increased blood supply and is more prone to fracture.

This disease is named after a surgeon, Sir James Paget, who first described the condition as a chronic inflammation of bone and called it, Osteitis deformans Osteitis means swelling of bone and Deformans means deformity.

However, sometimes patients may present with minor complaints, most common being the bone pain. As per recent statistical reports, 1 to 3 million people in the U.

It is the second most common disease of the bone after osteoporosis. However, a strong genetic predisposition has been considered a major cause of the condition.

If not recognized and treated at an early stage, it may progress to bone cancer, which can eventually cause death. However, the progression of the disease to bone cancer is rare.

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Hence, it is necessary that the general population is aware of the disease and appropriate interventions must be taken at an early stage.

However, it may worsen the condition in the pre-existing site. It may affect a single bone or multiple bones at a time. It refers to the involvement of only one bone. It refers to the involvement of 2 or more bones. However, it may present with some symptoms in minority of cases.

The most common symptom is bone pain. The clinical presentation depends on the bone involved, as described below: The occurrence of for such symptoms is due to the fact that nerves lie around the bones. Involvement of pelvic bone manifests as hip pain. Fracture of the Involved Bone: Warmer Skin Over the Affected Area: This is due to rich blood supply to the newly formed bone in the disease.

Hence, whenever there is trauma to the bone, the bleeding from the affected bone is more in comparison to healthy bone. It is a degenerative condition affecting the joints.

Paget's disease of bone - Diagnosis and treatment - Mayo Clinic

When there is bowing of legs, the adjoining joints may experience extreme stress due to abnormal mechanics and can lead to joint pain and inflammation.

It manifests as joint pain. When there is abnormal bone formation, the heart has to work harder to pump blood to the affected area so as to maintain adequate circulation. This increases the work load on the heart that can lead to heart failure. Scientifically, it is termed as Osteosarcoma.

Fracture neck of femur is a type of hip fracture seen in elderly people. An unsteady gait or reduced bone mineral density, both of which may be seen in the elderly is a predisposing factor. Nervous system problems. Bone with Paget’s disease can press on the brain, spinal cord, or nerves. This can slow blood flow to the brain and spinal cord and cause pain. Bone cancer. Rarely, people with Paget’s disease get cancer of the bone. This can cause sudden or increased bone pain. Loose teeth. Paget's disease is a chronic condition of bone characterized by disorder of the normal bone remodeling process. Normal bone has a balance of forces that act to lay down new bone and take up old bone.

It is marked by sudden, severe localized pain in the bone along with the presence of a soft tissue mass. Though rare, it is an extremely aggressive cancer and can be fatal. These are as follows: Hence, a person is at a greater risk if any of his family members is suffering from the disease.

However, as the disease is usually asymptomatic in the earlier stages, it is diagnosed when an individual is in his 50s. It is less commonly seen in Asia and Scandinavia.Paget's disease of bone is a chronic disease of the skeleton. In healthy bone, a process called remodeling removes old pieces of bone and replaces them with new, fresh bone.

Paget’s disease causes this process to shift out of balance, resulting in new bone that is abnormally shaped, weak, and brittle.

Paget's disease of bone (commonly known as Paget's disease or historically, osteitis deformans) is a condition involving cellular remodeling and deformity of one or more srmvision.com affected bones show signs of dysregulated bone remodeling at the microscopic level, specifically excessive bone breakdown and subsequent disorganized new bone .

BONE DISEASES TREATMENT Treatment options may vary, and often depend on the patient’s age, overall health, extent of the disease, the patient’s ability to tolerate treatments, the expected progression of the disease, and the patient’s preference.

Paget's disease of bone (commonly known as Paget's disease or historically, osteitis deformans) is a condition involving cellular remodeling and deformity of one or more srmvision.com affected bones show signs of dysregulated bone remodeling at the microscopic level, specifically excessive bone breakdown and subsequent disorganized new bone formation.

Paget disease of the breast is a rare type of cancer involving the skin of the nipple and, usually, the darker circle of skin around it, known as the areola.; Most of the time, people with Paget disease of the breast also have one or more tumors inside the same breast.

Paget’s disease is a treatable condition that affects the bones, mainly in older people. Affected bones become enlarged, misshapen and weaker than normal.

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